Journal
INFECTION AND IMMUNITY
Volume 73, Issue 1, Pages 617-621Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.1.617-621.2005
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- PHS HHS [A133325] Funding Source: Medline
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We investigated the role of interieukin-17 (IL-17)/IL-17 receptor (IL-17R) -mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R(-/-) mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.
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