Journal
INFECTION AND IMMUNITY
Volume 73, Issue 1, Pages 79-87Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.1.79-87.2005
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Funding
- NCRR NIH HHS [RR17686, P20 RR017686] Funding Source: Medline
- NIAID NIH HHS [AI55052, R21 AI050785, AI50785, R01 AI055052] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR017686] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI055052, R21AI050785] Funding Source: NIH RePORTER
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Ehrlichia chaffeensis, a tick-transmitted rickettsial agent, causes human monocyte/macrophage-tropic ehrlichiosis. In this study, proteomic approaches were used to demonstrate host cell-specific antigenic expression by E. chaffeensis. The differentially expressed antigens include those from the 28-kDa outer membrane protein (p28-Omp) multigene locus. The proteins expressed in infected macrophages are the products of p28-Omp19 and p28-Omp20 genes, whereas in tick cells, the protein expressed is the p28-Omp14 gene product. The differentially expressed proteins are posttranslationally modified by phosphorylation and glycosylation to generate multiple expressed forms. Host cell-specific protein expression is not influenced by growth temperatures and is reversible. Host cell-specific protein expression coupled with posttranslational modifications may be a hallmark for the pathogen's adaptation to a dual-host life cycle and its persistence.
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