Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 90, Issue 1, Pages 198-202Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2004-1083
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Cerebrospinal fluid (CSF) levels of rT(3) were evaluated in 21 euthyroid patients with overt Alzheimer's disease ( AD) and 18 matchedhealthy controls. The assessment also included transthyretin and total T(3) and T(4) CSF concentrations. Despite normal circulating thyroid hormone levels, AD subjects showed significantly increased rT(3) levels and an increased rT(3) to T(4) ratio in the face of unchanged CSF total T(4) and transthyretin levels. These results suggest an abnormal intracerebral thyroid hormone metabolism and possibly the occurrence of brain hypothyroidism, either as a secondary consequence of the ongoing process or as a cofactor in the progression of the disease.
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