Journal
ANNALS OF NEUROLOGY
Volume 57, Issue 1, Pages 98-103Publisher
WILEY-LISS
DOI: 10.1002/ana.20318
Keywords
-
Categories
Funding
- NATIONAL INSTITUTE ON AGING [Z01AG007280, U01AG019349, ZIAAG007270, R01AG017155, ZIAAG007280, Z01AG007270] Funding Source: NIH RePORTER
- NIA NIH HHS [5R01 AG 017155-01, 1U01 AG 19349-01] Funding Source: Medline
Ask authors/readers for more resources
Neocortical neuritic plaques and nettrofibrillary tangles are hallmark neuropathological lesions of dementia. Concomitant cerebrovascular lesions increase dementia severity in patients meeting neuropathological criteria for Alzheimer's disease and contribute to cognitive impairment in persons with mild entorhinal Alzheimer lesions. This study investigates whether individuals with sparse neocortical neuritic plaques experience increased odds of crossing the threshold to clinical dementia when they have coexistent cerebrovascular lesions. Dementia examinations were given to 3,734 men during the 1991-1993 Honolulu-Asia Aging Study examination and to 2,603 men during the 1994-1996 examination. Lesion quantification was done without clinical data. Among 333 autopsied men, 120 had dementia, 115 had marginal results, and 98 had normal cognition. In men with neurofibrillary tangles, dementia frequency increased with increasing neuritic plaque density, and increased further in the presence of cerebrovascular lesions. The association was strongest in men with sparse neuritic plaques (1-3/mm(2)) where dementia frequency more than doubled with coexistent cerebrovascular lesions (45 vs 20%). Among all dementia cases, 24% were linked to cerebrovascular lesions. Findings suggest cerebrovascular lesions are associated with a marked excess of dementia in cases with low neuritic plaque frequency. Prevention of cerebrovascular lesions may be critically important in preserving late-life cognitive function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available