Journal
FEMS MICROBIOLOGY LETTERS
Volume 242, Issue 1, Pages 101-108Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2004.10.045
Keywords
melioidosis; Blurkholderia pseudomallei; type III secretion; animal studies; attenuation
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Burkholderia pseudoinallei, the etiological agent of melioidosis, is an animal pathogen capable of inducing a highly fatal septicemia. R pseudomallei possesses three type III secretion system (TTSS) clusters, two of which (TTSS I and TTSS2) are homologous to the TTSS of the plant pathogen Ralstonia solanacearum, and one (TTSS3) is homologous to the Salmonella SPI-I mammalian pathogenicity island. We have demonstrated that TTSS3 is required for the full virulence of B. pseudomallei in a hamster model of infection. We have also examined the virulence of R pseudomallei mutants deficient in several putative TTSS3 effector molecules, and found no significant attenuation of B. pseudomallei virulence in the hamster model. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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