Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 191, Issue 1, Pages 4-10Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/426513
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Funding
- NIAID NIH HHS [AI43638, AI27660] Funding Source: Medline
- NICHD NIH HHS [R 01 HD41224] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD041224] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI043638, U01AI027660] Funding Source: NIH RePORTER
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The relationship between hepatitis C virus (HCV) genotype and HCV and human immunodeficiency virus (HIV) type 1 disease is not well defined. The present study analyzed data from a cohort of 207 HIV-1-infected and 126 HIV-1-uninfected children and adolescents with hemophilia who enrolled in the Hemophilia Growth and Development Study and were followed for 7 years. The mean HCV RNA level was higher in the participants in the HCV genotype 1 group than in the participants the HCV non-genotype 1 group, among both the HIV-1 -infected (difference, +0.33 log(10) copies/mL;) and HIV-1-uninfected (difference, +0.59 log(10) copies/P = .008) participants. Although HCV genotype was not associated with differences in HIV-1 RNA level, a significantly lower mean CD4(+) T cell count (difference, -127 cells/muL; P = .026) and percentage of CD4(+) T cells (difference, -4.3%; P = .027) were observed in the participants in the HCV genotype 1 group, compared with those in the participants in the HCV non-genotype 1 group. In addition, the participants in the HCV genotype 1 group were at increased risk for progression to AIDS-related mortality (hazard ratio, 2.44; P = .037). The present study suggests that HCV infection and genotype may influence the natural history of HCV and HIV-1 disease.
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