Journal
JOURNAL OF NEUROTRAUMA
Volume 22, Issue 9, Pages 1011-1017Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2005.22.1011
Keywords
erythropoietin; neurogenesis; neuroprotection; rat; traumatic brain injury
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042259] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS 42259] Funding Source: Medline
- OAPP OPHS HHS [PPG NS 23393] Funding Source: Medline
Ask authors/readers for more resources
Erythropoietin (EPO) is neuroprotective in models of stroke and traumatic brain injury (TBI) when administered prior to or within the first few hours after injury. We seek to demonstrate that EPO also has neurorestorative effects when administered late (i.e., 1 day) after TBI in the rat. Twelve rats were subjected to TBI. Six rats were treated with EPO daily for 14 days starting 1 day after injury, and an additional six rats were treated with saline. Bromodeoxyuridine (BrdU) was administered daily for 14 days. Memory tests using a Morris Water Maze were performed prior to and after injury and treatment. Animals were sacrificed at 15 days after TBI, and their brains were prepared for histological analysis of damage to the dentate gyrus (DG) and for evaluation of newly formed neurons using double labeling of BrdU and MAP-2. The data revealed a significant improvement in spatial memory and significant increase in the number of newly formed neurons with EPO treatment compared with control animals. These data suggest that EPO treatment initiated 1 day after TBI is neurorestorative by enhancing neurogenesis, as well as neuroprotective.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available