Journal
BEHAVIOURAL PHARMACOLOGY
Volume 16, Issue 5-6, Pages 441-446Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008877-200509000-00017
Keywords
cannabinoid CB1 receptors; dopamine D-2 receptors; quinpirole; psychomotor hyperactivity; chronic HU-210; rat
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The present study investigated spontaneous and quinpirole-induced motor responses of in rats, following withdrawal from chronic treatment with the potent cannabinoid agonist HU-210. Withdrawal from chronic HU-210 (20 mu g/kg daily, 14 days) produced a decrease in spontaneous activity at 1 and 2 days and enhanced the hyperactivity induced by acute administration of the dopamine D-2 agonist quinpirole (0.5 mg/kg) at 4 days after the end of HU-210 treatment. Administration of quinpirole on day 4 of withdrawal from chronic HU-210 enhanced stereotyped responses and induced jumping behaviour. These results suggest that withdrawal from chronic exposure to cannabinoid agonists could induce a time-dependent alteration in dopamine D-2 psychomotor function, leading to a behavioural disorganization, comparable to acute psychotic episodes after continuous cannabinoids.
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