Journal
NEURON
Volume 47, Issue 5, Pages 633-636Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2005.07.018
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Funding
- NIDA NIH HHS [R01 DA015718-03, R01-DA015718, R01 DA015718] Funding Source: Medline
- NINDS NIH HHS [T32 NS007375, T32-NS07375] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [T32NS007375] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA015718] Funding Source: NIH RePORTER
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Orbitofrontal cortex is characterized by its unique pattern of connections with subcortical areas, such as basolateral amygdala. Here we distinguish between the critical role of these areas in associative learning and the pivotal contribution of OFC to the manipulation of this information to control behavior. This contribution reflects the ability of OFC to signal the desirability of expected outcomes, which requires the integration of associative information with information concerning internal states and goals in representational memory.
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