Journal
NANO LETTERS
Volume 5, Issue 1, Pages 1-4Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl0484898
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Funding
- NIBIB NIH HHS [R01 EB005866] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB005866] Funding Source: NIH RePORTER
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Self-assembled peptide amphiphile nanofibers have been investigated for their potential use as in vivo scaffolds for tissue engineering and drug delivery applications. We report here the synthesis of magnetic resonance (MR) active peptide amphiphile molecules that self-assemble into spherical and fiber-like nanostructures, enhancing T, relaxation time. This new class of MR contrast agents can potentially be used to combine high-resolution three-dimensional MR fate mapping of tissue-engineered scaffolds with targeting of specific cellular receptors.
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