Journal
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Volume 61, Issue -, Pages 157-166Publisher
WILEY
DOI: 10.1002/prot.20733
Keywords
Rosetta; fragment assembly; de novo modeling; homology modeling; parametric alignment ensemble
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The Robetta server and revised automatic protocols were used to predict structures for CASP6 targets. Robetta is a publicly available protein structure prediction server (http://robetta. bakerlab.org/) that uses the Rosetta de novo and homology modeling structure prediction methods. We incorporated some of the lessons learned in the CASP5 experiment into the server prior to participating in CASP6. We additionally tested new ideas that were amenable to full-automation with an eye toward improving the server. We find that the Robetta server shows the greatest promise for the more challenging targets. The most significant finding from CASP5, that automated protocols can be roughly comparable in ability with the better human-intervention predictors, is repeated here in CASP6.
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