Journal
DEVELOPMENT
Volume 132, Issue 1, Pages 49-60Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.01564
Keywords
Hh; Wnt; osteoblast; mouse
Categories
Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P01HD039952] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [T32AR007033] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK065789] Funding Source: NIH RePORTER
- NIAMS NIH HHS [5T32AR07033] Funding Source: Medline
- NICHD NIH HHS [HD39952] Funding Source: Medline
- NIDDK NIH HHS [DK065789] Funding Source: Medline
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Signals that govern development of the osteoblast lineage are not well understood. Indian hedgehog (Ihh), a member of the hedgehog (Hh) family of proteins, is essential for osteogenesis in the endochondral skeleton during embryogenesis. The canonical pathway of Wnt signaling has been implicated by studies of Lrp5, a co-receptor for Writ proteins, in postnatal bone mass homeostasis. In the present study we demonstrate that beta-catenin, a central player in the canonical Writ pathway, is indispensable for osteoblast differentiation in the mouse embryo. Moreover. we present evidence that Writ signaling functions downstream of Ihh in development of the osteoblast lineage. Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development.
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