Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 53, Issue 1, Pages 118-125Publisher
WILEY
DOI: 10.1002/mrm.20304
Keywords
diffusion tensor imaging; fractional anisotropy; icosahedral encoding; spinal cord
Funding
- NCRR NIH HHS [S10 RR17205] Funding Source: Medline
- NINDS NIH HHS [NS 30821] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR017205] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS030821] Funding Source: NIH RePORTER
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Regional values of fractional anisotropy (FA) and mean diffusivity (D-av) of in vivo and excised rat spinal cords were measured using an iscosahedral encoding scheme that is based on 21 uniformly distributed and alternating gradient directions with an echo planar imaging (EPI) readout. Based on the water phantom studies, this scheme was shown to provide unbiased estimation of FA. The stability of the scanner during the acquisition of diffusion tensor imaging (DTI) data was evaluated. Repeated measurements of the FA values demonstrated excellent reproducibility, as assessed by the Bland-Altman analysis. These studies demonstrated a reduced anisotropy in excised samples relative to in vivo cords. Diffusion in the spinal cord gray matter was shown to be anisotropic. The FA value in the dorsal white matter (WM) was found to be higher relative to the ventral WM. Results from these studies should provide the necessary baseline data for serial in vivo DTI of injured spinal cord. (C) 2004 Wiley-Liss, Inc.
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