Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 19, Issue 19, Pages 2801-2808Publisher
WILEY
DOI: 10.1002/rcm.2126
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Ion suppression, a matrix effect that affects quantitative mass spectrometry, is one of the main problems encountered in liquid chromatography/tandem mass spectrometry. Two different clean-up steps for the multi-residue analysis of beta-agonists in urine were evaluated with respect to minimisation of ion suppression, namely, a mixed-phase solid phase extraction (SPE) column, i.e., clean screen Dan (CSD), and a molecular imprinted polymer (MIP) SPE column. Ion suppression experiments revealed that CSD sample clean-up can lead to false negative results for some beta-agonists, and that clean-up using MIP columns is more selective for beta-agonists than the use of CSD columns. Copyright (C) 2005 John Wiley & Sons, Ltd.
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