Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 204, Issue 3, Pages 750-762Publisher
WILEY
DOI: 10.1002/jcp.20356
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Protein-protein interactions play a key role in various mechanisms of cellular-growth and differentiation, and in the replication of pathogen organisms in hostcells. Thus, inhibition of these interactionsisa promisingnovel approach for rational drug design against a wide number of cellular and microbial targets. In the past few years, attempts to inhibit protein-protein interactions using antibodies, peptides, and synthetic or natural small molecules have met with varying degrees of success, and these will be the focus of this review.
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