Journal
CARDIOVASCULAR RESEARCH
Volume 67, Issue 4, Pages 594-603Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2005.05.005
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM070628] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01GM070628] Funding Source: Medline
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Renal ischemia-reperfusion (I/R) is an important etiopathological mechanism of acute renal failure (ARF). Despite improvements in the treatment of ARF, it is associated with significant morbidity and mortality. I/R injury also occurs during renal transplantation and leads to reduced allograft survival. Sex differences have been found in I/R injury in many different organs including the kidney. Women have half the mortality of men in ARE In animal models also, females are protected against renal I/R injury. The mechanisms by which sex affects the outcome to renal I/R injury are being actively investigated. This review will examine the evidence for gender differences in renal I/R injury and discuss the probable mechanisms by which sex affects the renal response to I/R injury. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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