Integrins in pulmonary inflammatory diseases

Integrins are a family of heterodimeric transmembrane glycoproteins that mediate cell-cell and cell-matrix interactions. They participate ill inflammatory reactions mainly by regulation of leukocyte migration, activation and survival. Elevated expression of the cell adhesion molecules, such as VCAM. ICAM and MAdCAM oil the lumenal surface Of Vascular endothelial cells is a critical early event in organ inflammatory processes - including the lung. Adhesive interactions with their counter-receptors on leukocytes, selectins and integrins, result in migration of the leukocytes to the inflammed tissues. Integrins also participate in physiological and pathological reorganization of the lung structure during e.g. pneumonia healing, airway remodeling, angiogenesis. emphysema and pulmonary flibrosis. Agents that Could inhibit the function of one or more of these integrins Could provide a novel therapeutic strategy targeted to inhibit inflammatory and immune phenomena in the lung.