4.3 Article

Cycloisomerization of olefinic carboxylic acids catalyzed by trifluoromethanesulfonic acid

Journal

SYNTHETIC COMMUNICATIONS
Volume 35, Issue 1, Pages 153-160

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1081/SCC-200046534

Keywords

lactones; cyclization; trifluoromethanesulfonic acid; unsaturated carboxylic acids

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The trifluoromethanesulfonic acid-catalyzed cyclization of various differently substituted unsaturated carboxylic acids affords selectively substituted lactones in good yields. The reactions use 0.5 to 5% molar ratio of catalyst and can be run without solvent.

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