Four new neuroprotective dihydropyranocoumarins from Angelica gigas

Four new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4-hydroxytigloyldecursinol (1), 4-hydroxydecursin (2),(2S,3S)-epoxyangeloyldecursinol (3), and (2R,3R)-epoxyangeloyldecursinol (4), respectively. All four new dihydropyranocoumarins and major coumarin derivatives of A. gigas, decursinol and decursin, exhibited signficant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells at concentrations ranging from 0.1 to 10 muM.