Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 22, Issue 1, Pages 174-177Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msh265
Keywords
synonymous sites; codon bias; evolutionary genomics; dS; dN/dS; selection
Funding
- NIGMS NIH HHS [GM 28424, GM 28016] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM028016] Funding Source: NIH RePORTER
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Evolution at silent sites is often used to estimate the pace of selectively neutral processes or to infer differences in divergence times of genes. However, silent sites are subject to selection in favor of preferred codons, and the strength of such selection varies dramatically across genes. Here, we use the relationship between codon bias and synonymous divergence observed in four species of the genus Saccharomyces to provide a simple correction for selection on silent sites.
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