Journal
PHYTOCHEMISTRY
Volume 66, Issue 1, Pages 5-29Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2004.10.022
Keywords
Uncaria tomentosa; cat's claw; rubiaceae; uncarines; quinovic acid; oxindole alkaloids; pentacyclic triterpenes; immunomodulatory; anti-inflammatory; vascular
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R15GM059049] Funding Source: NIH RePORTER
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The Uncaria genus is an important source of medicinal natural products, particularly alkaloids and triterpenes. The collected information is an attempt to cover the more recent developments in the ethnobotany, pharmacology and phytochemistry of this genus. During the past 20 years, alkaloids, terpenes, quinovic acid glycosides, flavonoids and coumarins have been isolated from Uncaria. Fifty-three novel structures are reported in this review. The species in which the largest number of compounds has been identified is the Peruvian Uncaria tomentosa or 'cat's claw.' Pharmacological studies are described according to cytotoxicity, anti-inflammatory, antiviral, immuno stimulation, antioxidant, CNS-related response, vascular, hypotensive, mutagenicity and antibacterial properties. The potential for development of leads from Uncaria continues to grow, particularly in the area of immunomodulatory, anti-inflammatory and vascular-related conditions. The information summarized here is intended to serve as a reference tool to practitioners in the fields of ethnopharmacology and natural products chemistry. (C) 2004 Published by Elsevier Ltd.
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