Journal
SYNTHETIC COMMUNICATIONS
Volume 35, Issue 18, Pages 2409-2413Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910500189569
Keywords
bifunctional chelating agent; bioconjugate chemistry; DTPA; labeling; maleimide linker; thiol
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An extremely easy and multigram scale synthesis of a new maleimide-DTPA derivative is described. This bifunctional chelating agent finds application in bioconjugate chemistry because the maleimido group allows easy labeling of thiol-containing molecules (e.g., proteins, peptides) and the DTPA moiety ensures a strong and stable coordination of metal and radiometal ions such as gadolinium, lutetium, indium, and yttrium.
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