Journal
SYNTHETIC COMMUNICATIONS
Volume 35, Issue 2, Pages 231-241Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/SCC-200048433
Keywords
ionic liquid; 2-amino benzamide; benzoyl chlorides; 2-aryl-4(3H)-quinazolinones
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An efficient one-pot synthesis of 2-aryl-4(3H)-quinazolinones from 2-amino benzamides and substituted benzoyl chlorides in a room temperature ionic liquid is described. Compared with the classical reaction conditions, this new synthetic method has the advantages of recyclability of ionic liquid, very good to excellent yields (78-92%), the absence of hazardous and expensive catalysts, and easy workup procedures giving rise to a process with minimum waste.
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