Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 433, Issue 1, Pages 176-192Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2004.08.032
Keywords
oxalate oxidase; oxalate decarboxylase; oxalyl-CoA decarboxylase; formyl-CoA transferase; Oxalobacter formigenes; hyperoxaluria; enzyme mechanism; protein structure
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Funding
- NIDDK NIH HHS [DK53556, DK61666] Funding Source: Medline
- NIGMS NIH HHS [GM18938] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK053556, R01DK061666, R56DK061666] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM018938, R37GM018938] Funding Source: NIH RePORTER
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Oxalate degrading enzymes have a number of potential applications, including medical diagnosis and treatments for hyperoxaluria and other oxalate-related diseases, the production of transgenic plants for human consumption, and bioremediation of the environment. This review seeks to provide a brief overview of current knowledge regarding the major classes of enzymes and related proteins that are employed in plants, fungi, and bacteria to convert oxalate into CO2 and/or formate. Not only do these enzymes employ intriguing chemical strategies for cleaving the chemically unreactive C-C bond in oxalate, but they also offer the prospect of providing new insights into the molecular processes that underpin the evolution of biological catalysts. (C) 2004 Elsevier Inc. All rights reserved.
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