Journal
CELL CYCLE
Volume 4, Issue 1, Pages 172-176Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.4.1.1350
Keywords
DNA replication; MHC region; genomic microarrays
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Genomic microarrays have been used to assess DNA replication timing in a variety of eukaryotic organisms.(1-3) A replication timing map of the human genome has already been published at a 1Mb resolution.(3) Here we describe how the same method can be used to assess the replication timing of chromosome 6 with a greater resolution using an array of overlapping tile path clones. We report the replication timing map of the whole of chromosome 6 in general, and the MHC region in particular. Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity.
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