Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 60, Issue 9, Pages 1190-1201Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/60.9.1190
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Funding
- NATIONAL INSTITUTE ON AGING [K12AG000294] Funding Source: NIH RePORTER
- NIA NIH HHS [K12 AG00294] Funding Source: Medline
- PHS HHS [A608812, A604390] Funding Source: Medline
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Homocysteine is a sulfur-containing amino acid that is involved in one-carbon metabolism. Hyperhomocystememia is a common phenomenon among elderly people. There is growing evidence of an association between hyper-homocystemennia and geriatric multisystem problems, including coronary artery disease, stroke, peripheral vascular disease, cognitive impairment, dementia, depression, osteoporotic fractures, and functional decline. The proposed mechanisms of the association include angiotoxicity, neurotoxicity, and inhibition of collagen cross-linking. A homocysteine-lowering strategy may prevent or slow the development of these age-related problems. Vitamin supplementation and folic acid fortification of grain foods have been shown to decrease plasma homocysteine concentrations. More research is needed to investigate whether lifelong homocysteine lowering can prevent the development of late-life morbidity.
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