Journal
LANCET NEUROLOGY
Volume 4, Issue 9, Pages 543-555Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(05)70165-4
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Funding
- NIMH NIH HHS [MH61438] Funding Source: Medline
- NINDS NIH HHS [NS35609, NS49465, NS44807] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH061438] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS049465, R01NS044807] Funding Source: NIH RePORTER
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Cognitive disorders, vacutolar myelopathy, and sensory neuropathies associated with HIV are the most common disorders in patients with HIV AIDS, and are the focus of this review. These disorders are treatable and of those associated with HIV AIDS the pathogenic mechanisms are the most understood. Although triggered by productive HIV macrophage infections, aberrant immune activation plays a major role in inducing the CNS disorders. Novel therapies aimed at these inflammatory mechanisms can be effective. The sensory neuropathies associated with HIV infection are a major cause of morbidity; incidence may be increased by the toxic effects of specific antiretroviral drugs within the peripheral nervous system.
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