Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 141, Issue 3, Pages 388-397Publisher
WILEY
DOI: 10.1111/j.1365-2249.2005.02824.x
Keywords
autoimmune; cytokine; fibroblasts; inflammation
Categories
Funding
- NEI NIH HHS [EY8976, R01 EY008976, EY11708, R01 EY011708] Funding Source: Medline
- NIDDK NIH HHS [R01 DK063121, DK063121] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY008976, R01EY011708] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK063121] Funding Source: NIH RePORTER
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Traditional wisdom has considered fibroblasts as contributing to the structural integrity of tissues rather than playing a dynamic role in physiological or pathological processes. It is only recently that they have been recognized as comprising diverse populations of cells exhibiting complex patterns of biosynthetic activity. They represent determinants that react to stimuli and help define tissue remodelling through the expression of molecules imposing constraints on their cellular neighbourhood. Moreover, fibroblasts can initiate the earliest molecular events leading to inflammatory responses. Thus they must now be viewed as active participants in tissue reactivity. In this short review, I will provide an overview of contemporary thought about the contribution of fibroblasts to the pathogenesis of autoimmune processes through their expression of, and responses to, mediators of inflammation and tissue remodelling. Keywords: autoimmune, cytokine, fibroblasts, inflammation and tissue remodelling.
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