Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 62, Issue 2, Pages 128-142Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-4254-1
Keywords
Drosophila; sphingolipids; molecular genetics; metabolism
Categories
Funding
- NATIONAL CANCER INSTITUTE [Z01BC010331, ZIABC010331] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Sphingolipids are important structural components of membranes that delimit the boundaries of cellular compartments, cells and organisms. They play an equally important role as second messengers, and transduce signals across or within the compartments they define to initiate physiological changes during development, differentiation and a host of other cellular events. For well over a century Drosophila melanogaster has served as a useful model organism to understand some of the fundamental tenets of development, differentiation and signaling in eukaryotic organisms. Directed approaches to study sphingolipid biology in Drosophila have been initiated only recently. Nevertheless, earlier phenotypic studies conducted on genes of unknown biochemical function have recently been recognized as mutants of enzymes of sphingolipid metabolism. Genome sequencing and annotation have aided the identification of homologs of recently discovered genes. Here we present an overview of studies on enzymes of the de novo sphingolipid biosynthetic pathway, known mutants and their phenotypic characterization in Drosophila.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available