New protocol for Biginelli reaction-a practical synthesis of Monastrol

A simple, efficient, and cost-effective method has been developed for the synthesis of 3,4-dihydropyrimidin- 2(1H)-ones by a one-pot three component cyclocondensation reaction of 1,3 dicarbonyl compound, aldehyde, and urea using benzyltriethylammonium chloride as the catalyst, under solvent-free conditions: the scope of this protocol is utilized for the synthesis of mitotic Kinesin EG5 inhibitor monastrol.