Journal
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume 28, Issue 12-13, Pages 2029-2039Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/JLC-200063666
Keywords
CCC; filamentous fungi; psychrophilin; LECA; LC-MS; dereplication; alkylphenones; Margraff system; Penicillium rivulum
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Analytical standardised reversed phase liquid chromatography (RPLC) data can be helpful in finding a suitable solvent combination for isolation of fungal metabolites by high-speed counter current chromatography. Analysis of the distribution coefficient (K-D) of fungal metabolites in a series of biphasic systems consisting of n-heptane-ethyl acetate (EtOAc)-methanol (MeOH)-water has been used to illustrate the relationship between the RPLC retention indexes and K-D's. The relationship can be used to select a suitable solvent combination for HSCCC, as demonstrated by the isolation of two new cyclic peptides from a crude fungal extract.
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