Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 24, Issue 5-7, Pages 485-489Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/NCN-200061774
Keywords
phosphoramidate; protide; anticancer
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The phosphoramidate technology we have developed has been recently applied to BVdU, leading to NB1011 (NewBiolics Inc., California), a novel potential anticancer compound recently entered into Phase 2 of the clinical trials for colon cancer. We report in this work a new series of derivatives containing naphthol as aryl masking group on the phosphate moiety, which has shown a significant increase in anticancer activity in preliminary biological evaluations.
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