Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 99, Issue 1, Pages 23-33Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2004.10.024
Keywords
globin-coupled sensor; protoglobin; signal transduction; globin; LUCA
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The strategy for detecting oxygen, carbon monoxide, nitric oxide, and sulfides is predominantly through heme-based sensors utilizing either a globin domain or a PAS domain. Whereas PAS domains bind various cofactors, globins bind only heme. Globin-coupled sensors (GCSs) were first described as regulators of the aerotactic responses in Bacillus subtilis and Halobacterium salinarum. GCSs were also identified in diverse microorganisms that appear to have roles in regulating gene expression. Functional and evolutionary analyses of the GCSs, their protoglobin ancestor, and their relationship to the last universal common ancestor (LUCA) are discussed in the context of globin-based signal transduction. (C) 2004 Published by Elsevier Inc.
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