Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 99, Issue 1, Pages 237-246Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2004.10.034
Keywords
nitrite; hemoglobin; hypoxia; vasodilation
Funding
- NHLBI NIH HHS [HL70146, R01 HL058091, HL58091] Funding Source: Medline
- NIGMS NIH HHS [GM55792] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R37HL058091, R01HL070146, R29HL058091, R01HL058091] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R29GM055792, R01GM055792] Funding Source: NIH RePORTER
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The reaction between nitrite and hemoglobin has been studied for over a century. However, recent evidence indicating nitrite is a latent vasodilatory agent that can be activated by its reaction with deoxyhemoglobin has led to renewed interest in this reaction. In this review we survey, in the context of our own recent studies, the chemical reactivity of nitrite with oxyhemoglobin, deoxyhemoglobin and methemoglobin, and place these reactions in both a physiological and pharmacological/therapeutic context. (C) 2004 Elsevier Inc. All rights reserved.
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