Journal
HELVETICA CHIMICA ACTA
Volume 88, Issue 7, Pages 1734-1753Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200590136
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For the first time, uncatalyzed, high-pressure (0.6 GPa) reactions with ketones have proven to be a powerful way to perform the three-component Strecker synthesis of a-amino nitrites in high yields. Two types of double Strecker reactions were achieved, but attempts to perform triple Strecker reactions were unsuccessful.
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