Journal
PEDIATRIC BLOOD & CANCER
Volume 44, Issue 1, Pages 8-12Publisher
WILEY
DOI: 10.1002/pbc.20165
Keywords
Down syndrome; epidemiology; leukemia; risk factors
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Funding
- NATIONAL CANCER INSTITUTE [R01CA075169, U10CA098543] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA075169, R01-CA75169, U01-CA98543] Funding Source: Medline
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Studies suggest nearly a 20-fold increased risk of leukemia in individuals with Down syndrome. Most of this increased risk appears in the first few decades of life, with the highest incidence in children less than 5 years of age. It is unknown why children with Down syndrome are at such an increased risk of leukemia. With respect to environmental exposures, it will be important to investigate risk factors associated with childhood leukemia in general (including diagnostic x-rays, pesticides, and other occupational exposures) as well as experiences common to children with Down syndrome (including routine medical screening tests, increased susceptibility to infections, and increased vitamin deficiencies). (C) 2004 Wiley-Liss, Inc.
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