Journal
EMBO REPORTS
Volume 6, Issue 1, Pages 33-38Publisher
WILEY
DOI: 10.1038/sj.embor.7400325
Keywords
double-stranded RNA-binding motif; RNA-binding proteins; RNA recognition; RNA-recognition motif; zinc-finger motif
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At all stages of its life ( from transcription to translation), an RNA transcript interacts with many different RNA-binding proteins. The composition of this supramolecular assembly, known as a ribonucleoprotein particle, is diverse and highly dynamic. RNA-binding proteins control the generation, maturation and lifespan of the RNA transcript and thus regulate and influence the cellular function of the encoded gene. Here, we review our current understanding of protein-RNA recognition mediated by the two most abundant RNA-binding domains (the RNA-recognition motif and the double-stranded RNA-binding motif) plus the zinc-finger motif, the most abundant nucleic-acid-binding domain. In addition, we discuss how not only the sequence but also the shape of the RNA are recognized by these three classes of RNA-binding protein.
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