Journal
JOURNAL OF ENVIRONMENTAL MONITORING
Volume 7, Issue 3, Pages 189-195Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b413506g
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The results of a degradation study of the (fluoro) quinolone antibiotics ciprofloxacin and oxolinic acid in river water samples are presented in this paper. The decomposition of these compounds at ambient temperature was monitored during five months by HPLC-UV, and two consecutive degradation processes ( photo- and bio/chemical- degradation) were observed in both cases although with different degradation rates. Ciprofloxacin was completely degraded after 3 months whereas 80% of oxolinic acid remained unaltered after five months of storage. The analysis of the degradation compounds formed was carried out using MS and tandem MS-MS, allowing the identification of four new ciprofloxacin transformation products not previously described in the literature. Possible degradation pathways for this antibiotic in river water are proposed.
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