Journal
PEDIATRIC BLOOD & CANCER
Volume 44, Issue 1, Pages 95-97Publisher
WILEY
DOI: 10.1002/pbc.20187
Keywords
asparaginase; child; conservative therapy; necrotizing pancreatitis; percutaneous drainage
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L-asparaginase is a key component of the antileukemic therapy in children with acute lymphoblastic leukemia (ALL). Pancreatitis has been noted to he a complication in 2-16% of patients undergoing treatment With L-asparaginase for a variety of pediatric neoplasms. Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation. However, in tare instances, hemorrhagic pancreatitis or necrosis may occur. L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia. We present a pediatric patient with leukemia and a L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts. (C) 2004 Wiley-Liss, Inc.
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