Journal
EXPERT OPINION ON PHARMACOTHERAPY
Volume 7, Issue 8, Pages 975-987Publisher
ASHLEY PUBLICATIONS LTD
DOI: 10.1517/14656566.7.8.975
Keywords
doxorubicin; gemcitabine; ovarian cancer; resistance; topotecan
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Ovarian cancer is more fatal than all the other gynaecolological malignancies combined. Although most patients respond to first-line combination chemotherapy, the vast majority (50-75%) of patients with advanced disease will relapse. The management of patients with recurrent ovarian cancer is based on their response profile to platinum: patients with platinum-sensitive disease can be rechallenged with platinum-based chemotherapy, whereas the management of patients with platinum-resistant or -refractory disease remains an area of active investigation. In this review, the data for second-line therapy in this latter group of patients will be summarised and recommendations for their optimal management will be made.
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