Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 11, Issue -, Pages 380-388Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/1805
Keywords
co-evolutionary relationship; hormone; insulin; IGF-I signaling pathway; distance matrix; correlation coefficient
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Insulin/insulin like growth factor 1 signaling pathway plays an essential role on the regulation of variant, interrelated and fundamental processes, such as metabolism, growth, reproduction and aging. This pathway is highly conserved during evolution. We analyzed eight vertebrate species' insulin/insulin like growth factor 1 pathway and examined the co-evolutionary relationship between different protein components by quantifying similarity of phylogenetic trees. The collected species include Takifugu rubripes, Danio rerio, Xenopus laevis, Gallus gallus, Mus musculus, Rattous norvegicus, Pan troglodytes and Homo sapiens. Results show that interacting proteins in this pathway share highly co-evolutionary relationship while contrarily the proteins without interaction have low co-evolutionary relationship. We also predict some receptor and ligand partners enjoy highly binding potential in corresponding species' pathway.
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