Antimicrobial properties of highly fluorinated silver(I) tris(pyrazolyl)borates

Highly fluorinated tris(pyrazolyl)borate ligand [HB(3,5-(CF3)(2)Pz)(3)](-) has been used in the isolation of air- and light-stable silver complex, [HB(3,5-(CF3)(2)Pz)(3)]Ag(OSMe2). It is a monomeric tetrahedral silver complex with an O-bonded dimethylsulfoxide ligand. The silver adduct [HB(3,5-(CF3)(2)Pz)(3)]Ag(OSMe2) and the related [HB(3,5-(CF3)(2)Pz)(3)] Ag(THF) (where OSMe2 = dimethyl sulfoxide; THF = tetrahydrofuran) show good antibacterial activity, and their antimicrobial efficacy against Staphylococcus aureus is greater than those of AgNO3 and silver sulfadiazine. (C) 2005 Elsevier Inc. All rights reserved.