Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 101, Issue -, Pages 355-357Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762006000900058
Keywords
Schistosoma mansoni; immunodiagnosis; synthetic peptides
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The immunoreactivity of seven peptides synthesized from Schistosoma mansoni proteins, was evaluated by dotblot and ELISA assays using two different sensitization methodologies. The best results were obtained on wells of the Costar 3590 microplates coated with peptides P1, P2, P3, P6, and P7 using conventional methodology. The signals increased considerably (p < 0.0003) on wells sensitized with P1 to P6 using alternative methodology. In contrast, the well coated with peptide P7 presented lower signal when compared with conventional methodology (p = 0.0019). These results, establish the basis for the application of synthetic peptides for laboratory diagnosis of schistosomiasis mansoni.
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