Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 1, Pages 20-31Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1789
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The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse signalling pathways. All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell - cell adhesion.
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