Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 6, Issue 1, Pages 109-120Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737140.6.1.109
Keywords
Aurora A kinase; Aurora B kinase; clinical status; inhibitors; resistance; mutations
Categories
Ask authors/readers for more resources
Aurora A and B kinases are closely related kinases involved in regulating separate points in the cell cycle. This review highlights the rationale for Aurora kinases as cancer targets and examines the currently known Aurora kinase inhibitors in the patent and scientific literature. The known crystal structures of the Aurora kinases are described with relevance to bound ligand interactions and the prospect of the generation of drug-resistant mutant forms. The potential for selectivity versus primary cells will also be discussed. The status of the inhibitors in clinical development is described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available