Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 1, Pages 63-68Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1783
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The recent technological advance of using fluorescent proteins to image endocytic protein traffic has resulted in a greater understanding of this dynamic process. However, most of the main concepts for how clathrin-mediated endocytosis functions were formulated long before intrinsically fluorescent proteins were available. These important conceptual breakthroughs came from the clever interpretation of simple observations.
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