Journal
NATURAL PRODUCT RESEARCH
Volume 20, Issue 1, Pages 85-88Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/15216540500092898
Keywords
medicinal plants; Nothapodytes foetida; Ophiorrhiza mungos; Ophiorrhiza rugosa; camptothecin
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Camptothecin is an anticancer quinoline alkaloid effective against colon cancer. It acts by inhibition of the enzyme DNA topoisomerase I. A comparative study of camptothecin from the indigenous plants namely Nothapodytes foetida, Ophiorrhiza mungos and Ophiorrhiza rugosa indicated highest yields of camptothecin and 9-methoxy camptothecin in N. foetida. The other two plants O. mungos and O. rugosa contained low levels of alkaloids.
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