Journal
DRYING TECHNOLOGY
Volume 24, Issue 7, Pages 849-861Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07373930600734018
Keywords
excipients; freeze-drying; freezing; optimal control; pressure rise method
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Significance of pharmaceutical formulation (choosing of correct excipients in optimal quantities), effects of glass transition temperature, importance of theoretical modeling of the process, benefits of optimal control, and the advantages of remote monitoring of the process are presented. Experimental and theoretical research and development needs for the freeze-drying of pharmaceutical products are proposed and discussed.
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