Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 78, Issue 1, Pages 1-8Publisher
WILEY-LISS
DOI: 10.1002/jmv.20499
Keywords
SARS; neutralizing antibody; disease progression; vaccine
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Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.
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