Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 8, Issue 9-10, Pages 1857-1863Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2006.8.1857
Keywords
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [ZIAHL005012, Z01HL005012] Funding Source: NIH RePORTER
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There is growing experimental evidence that the production of intracellular reactive oxygen species (ROS) represents a tightly regulated process. In particular, numerous observations have suggested a role for the Ras superfamily of small GTPases in redox regulation. This article reviews the evidence that ROS can serve as important downstream effectors for both Ras and Rac proteins. Given the prominent role these proteins play in regulating growth, senescence, and transformation, understanding the role of the small GTPase family in redox regulation may significantly alter our current concepts as to how free radicals contribute to diverse processes from aging to cancer.
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